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MaxDataGenius Pro v1.9.5.2 Setup + Crack ~ [APKGOD]Low-dose gluten challenge in patients with untreated celiac disease: correlation of diagnostic tests with clinical manifestations.
The efficiency of enzyme-linked immunosorbent assay (ELISA) testing is a debated topic. This study is designed to evaluate the correlation of ELISA testing with the Marsh classification and with clinical symptoms in patients with untreated celiac disease (CD) during gluten challenge. CD patients (age range, 24-50 years) who had negative results on an initial laboratory study for CD (>/=2 years) were included. Patients were screened for a repeat celiac serology (anti-tissue transglutaminase [TTG] IgA or IgG, endomysium antibody [EMA], and deamidated gliadin peptide [DGP] IgA or IgG) and a low-dose gluten challenge (0.5-1.0 g/day) was performed. Clinical evaluation was also conducted. Among 68 individuals (43 females; age range, 24-50 years), 13 (19%) were found positive on ELISA. A total of 28 (41%) individuals (10 females; age range, 24-50 years) had flat mucosa, but none showed mild enteropathy. A total of 12 (17%) had arthritis and/or arthralgia, 4 (5%) had severe diarrhea, and all others had a symptomatology either similar to or comparable to the subclinical symptoms of CD. A total of 1 of the 13 positive individuals (8%) had tTG-IgA detectable by ELISA and 9 had negative results. A total of 39 (56%) individuals had subclinical symptoms, while 23 (33%) showed a positive pattern. The frequencies of the symptoms were comparable in the subclinically and the clinically positive group. The pattern of disease during gluten challenge in untreated CD is not affected by
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