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Sep 14, 2013
A:
Annotate that array element with the array name.
moncler outlet
)
You could still foreach it and iterate over it but that would mean a foreach loop would be ugly.
[unreadable] [unreadable] The aim of the proposed project is to explore the interplay between regulatory mutations in the IgA [unreadable] heavy chain (IgA [unreadable]) locus and superantigen-mediated exonuclease activity, specifically in the [unreadable] context of mucosal immunity. Preliminary data suggest that the loss of ability to detect or [unreadable] respond to superantigens results from a cryptic exonic polymorphism in the IgA [unreadable] locus, one which encodes a large number of regulatory mutations (e.g. germline [unreadable] mutations in the constant region (C [unreadable]) gene) that, when expressed, result in markedly [unreadable] increased expression of IgA [unreadable]. We hypothesize that the combined effect of [unreadable] regulatory mutations and exonuclease activity results in a loss of immunological self-tolerance [unreadable] and impaired gut mucosal immunity. To test this hypothesis, we have developed two Specific Aims. In Aim 1, we will test the hypothesis that regulatory mutations in the IgA locus modulate the [unreadable] induction and function of regulatory T cells and helper T cells (Th). In Aim 2, we will test the hypothesis that the [unreadable] superantigen-mediated exonuclease activity is responsible for a large number of IgA [unreadable] gene regulatory mutations that are found in humans. In addition to our established collaborative [unreadable] interactions with other PPG members, our proposed study will directly involve a highly [unreadable] experienced group of immunologists with extensive experience in both mucosal and [unreadable] cellular immunology, in particular Drs. Nussenzweig, Najarian, and Cox and an expanding [unreadable] group of scientists. These investigators have already generated preliminary data that will [unreadable] be critical for success of the proposed project. As a logical follow-up, our results will provide a [unreadable] rational
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