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Antibody-drug conjugates (ADCs) are a class of anticancer agents in which monoclonal antibodies targeting the cancer cell surface are linked by a chemical linker to a cytotoxic drug. This review will outline the progress to date in ADCs and the future directions in this field. Major developments include: (1) the introduction of new linkers that enhance ADC penetration into solid tumors and enhance stability and the elimination of hydrophobic drugs; (2) the use of ADC linkers to enhance the activity of cytotoxic drugs and (3) ADCs in which the cytotoxic drug is a peptide. Recent work will discuss the novel linkers now being investigated and their potential advantages. The use of ADC linkers to enhance the activity of drugs is now a mature and robust field and the development of new linkers may be less important. The third category, peptides, is very much in its infancy and currently limited by lack of ADC potency and host toxicity. Alternative cytotoxic drugs used in this third category will be discussed and suggestions made for the future./*
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