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Category:E-government in the United StatesBromoacetic acid-induced dominant lethal mutations in the mouse and their role in induction of tumorigenesis.
Rates of dominant lethal mutations in C57BL/6 mice were determined following treatment with bromoacetic acid (BAA) at a dose rate of 450 mumol kg-1 day-1 (13.4 g kg-1) for 20 weeks. The average induced dominant lethal mutation rate per gamete per generation was 0.086. Administration of BAA at a dose rate of 900 mumol kg-1 day-1 (27.2 g kg-1) resulted in an average induced dominant lethal mutation rate of 0.075. The sensitivity of the test was adequate to detect a dose rate of 2250 mumol kg-1 day-1 (68.0 g kg-1). With a positive control mutagen, 4-nitroquinoline-1-oxide (4NQO), at a dose rate of 2250 mumol kg-1 day-1 (68.0 g kg-1), the average induced dominant lethal mutation rate was 0.121. In a 6-week pilot study, mice were given i.p. injections of 4NQO, BAA, or a combination of the two, in doses, which were estimated to induce a rate of 0.1 or 0.2 dominant lethal mutation per gamete per generation. Animals were killed 7 weeks after the first injection. The average rate of dominant lethal mutations induced by BAA alone was 0.073 and the average rate by
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